Table 2.
Potency and Efficacy of FFAR2 Agonists at Mouse FFAR2
| mFFAR2 | ||
|---|---|---|
| Calcium | ||
| Acetate | pEC50 | 5.00 ± 0.01 (n = 13) |
| pEmax | 51.17 ± 13.06 | |
| SCA14 | pEC50 | 6.03 ± 0.52 (n = 5) |
| pEmax | 59.42 ± 26.50 | |
| SCA15 | pEC50 | 3.28 ± 0.432 (n = 3) |
| pEmax | 72.09 ± 27.91 | |
| CMTB | pEC50 | 6.53 ± 0.11 (n = 4) |
| pEmax | 34.07 ± 11.40 | |
| CPTB | pEC50 | 6.19 ± 0.24 (n = 4) |
| pEmax | 44.76 ± 12.58 |
pEC50 and pEmax values for each FFAR2 agonist in the calcium mobilization assays conducted in the βTC3 mouse β cell line is shown. NR refers to no response, where this indicates the absence of a calcium flux response to the agonsit during a multiple concentration titration. Shown are mean ± SEM.