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. 2015 Jun 3;29(7):1067–1079. doi: 10.1210/me.2015-1059

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Copyright © 2015 by the Endocrine Society

This article has been published under the terms of the Creative Commons Attribution License (CC-BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s).

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Figure 4. — GSIS is markedly impaired in βDicer-null islets early after tamoxifen injections. Insulin secretion in response to 30 minutes exposure to low or high glucose (Glu), alone or in combination with 0.5 mM mixed fatty acids (FA) (3:1 palmitate/oleic acid) and KCl (20 mM) in islets from control (C) or βDicer null (KO) mice, 2 weeks after tamoxifen injection, was measured using an HTRF-based assay. Incubations were performed in duplicate and involved 8 islets/tube (n = 3 mice/genotype). Data are presented as the percentage of insulin secreted vs total insulin content. *, P < .05; **, P < .01; ****, P < .0001; matched two-way ANOVA, Bonferroni test.