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Disruption of miRNA function does not result in impaired expression of β-cell signature genes. A and B, 7- to 8-week-old βDicer null (KO) or control Dicerflox/flox (C) mice were injected with 2 mg of tamoxifen for 5 consecutive days. Two weeks after the last injection, total RNA was extracted from isolated islets and RT-qPCR was used to evaluate the expression of the indicated genes (n = 7–12 mice/genotype). *, P < .05; **, P < .01, Student t test; ns, not significant.
