Table 1.
Hazard ratios for various cutoff values of HRG based on data from the HERALD study.
| Cutoff for HRG-high (∆Ct) group | Number of events | HR (pooled patritumab dose vs. placebo) for PFS in HRG-high group | Log-rank P-value |
|---|---|---|---|
| 2.7 (first quartile) | 24 (18) | 0.180 | 0.0039 |
| 3.0 | 33 (24) | 0.177 | 0.0009 |
| 3.5 | 46 (36) | 0.283 | 0.0009 |
| 3.9 (median) | 51 (41) | 0.324 | 0.0013 |
| 4.5 | 65 (50) | 0.490 | 0.0190 |
| 5.0 (third quartile) | 76 (58) | 0.561 | 0.0429 |
ΔCt: median delta threshold cycle; HR: hazard ratio; HRG: heregulin; PFS: progression-free survival.