Table 1.

Outstanding issues for implementing MRD in clinical decision-making in AML

Issue	Present Problems	Moving forward
Acceptance by clinicians	Understandable reluctance	Awaiting more clinical trials, e.g. AML17
Different platforms	Confusion, particularly for flow	Formalized proficiency testing
Expressing sensitivity	Different approaches	Agreement between working groups of common standard
MRD based decision-making	Scantily applied	Upfront incorporation, e.g. whether to transplant
What method to employ?	Lack of consistency	Initiate prospective comparisons between flow and RQ-PCR
Data reporting	Difficulties in interpretation	Common reporting packages incorporating graphics