TABLE 2.
Characteristic | Hospital A | Hospital B | Hospital C |
---|---|---|---|
No. enrolled | 823 | 666 | 632 |
No. admissions/mo | 27 (17, 34) | 17 (13, 30) | 18 (11, 30) |
Demographics | |||
Age, yrs | 2 (1, 5) | 3 (1, 7) | 2 (1, 7) |
Male gender | 57 | 53 | 52 |
White race | 29 | 65 | 84 |
Hispanic ethnicity | 8 | 19 | 30 |
Clinical | |||
Any comorbidity | 58 | 57 | 38 |
Direct ICU admission | 9 | 17 | 13 |
Pleural effusion | 9 | 12 | 23 |
Length of stay, h | 67 (45, 112) | 55 (38, 95) | 71 (42, 125) |
Antibiotic therapy preguidelinesa | |||
Third-generation cephalosporins (without/with macrolide) | |||
Without macrolide | 45 | 37 | 33 |
With macrolide | 15 | 20 | 9 |
Penicillin/ampicillin (without/with macrolide) | |||
Without macrolide | 1 | 4 | 9 |
With macrolide | <1 | <1 | <1 |
Other β-lactams | 5 | 11 | 13 |
Vancomycin/clindamycinb | 27 | 23 | 24 |
Other | 6 | 5 | 12 |
Guideline-related hospital activities | |||
Educational conferences | No | January 18, 2012 | November 10, 2011 |
Antibiotic recommendations disseminated to faculty | No | April 12, 2012 | No |
Other hospital activities | |||
Antimicrobial stewardship program | Yes, July 2011 | Yes, continuous | Yes, continuous |
CAP clinical practice guideline | No | No | No |
CAP electronic order set | Yesc | Yesc | No |
Values are expressed as median (IQR) or %.
Median monthly percentage of use during the period preguidelines (January 2010 to August 2011).
Monotherapy or in combination with other agents.
Order sets at both institutions recommended third-generation cephalosporins as first-line therapy and did not change during the study period.