TABLE 2.

Selected drug transporters

Transporter	Superfamily	Family	Gene Name	PDZ Ligand	Selected Substrates
OCT1	SLC	SLC22	SLC22A1	—	Metformin, oxaliplatin
OCT2	SLC	SLC22	SLC22A2	—	Metformin, ranitidine, varinicline
OCT3	SLC	SLC22	SLC22A3	R-S-H-L	Histamine, epinephrine
OCTN1	SLC	SLC22	SLC22A4	L-T-A-F	Quinidine, verapamil, ipratropium, ergothioneine
OCTN2	SLC	SLC22	SLC22A5	S-T-A-F	Carnitine, amisulpride, cephaloridine
OAT1	SLC	SLC22	SLC22A6	—	Lamivudine, acyclovir, ciprofloxacin
OAT2	SLC	SLC22	SLC22A7	—	Bumetanide, erythromycin, paclitaxel
OAT3	SLC	SLC22	SLC22A8	—	Furosemide, bumetanide
OAT4	SLC	SLC22	SLC22A11	S-T-S-L	Bumetanide, urate, methotrexate
URAT1	SLC	SLC22	SLC22A12	S-T-Q-F	Urate
OATP1A2	SLC	SLCO	SLCO1A2	K-T-K-L	Statins, fexofenadine
OATP1B1	SLC	SLCO	SLCO1B1	—	Statins, repaglinide, olmesartan
OATP1B3	SLC	SLCO	SLCO1B3	—	Statins, telmisartan, fexofenadine
OATP1C1	SLC	SLCO	SLCO1C1	E-T-Q-L	Triiodothyronine, thyroxine
OATP2B1	SLC	SLCO	SLCO2B1	D-S-R-V	Statins, fexofenadine
OATP3A1	SLC	SLCO	SLCO3A1	E-S-V-L	Benzylpenicillin, vasopressin
OATP4A1	SLC	SLCO	SLCO4A1	Q-S-S-V	Estradiol-17β-glucuronide
OATP4C1	SLC	SLCO	SLCO4C1	—	Digoxin, methotrexate, sitagliptin
PEPT1	SLC	SLC15	SLC15A1	Q-K-Q-M	Cephalexin, valacyclovir, enalapril
PEPT2	SLC	SLC15	SLC15A2	K-T-K-L	Cephalexin, valacyclovir, enalapril
MDR1 (Pgp)	ABC	ABCB	ABCB1	—	Digoxin, loperamide
BCRP	ABC	ABCG	ABCG2	—	Statins, methotrexate
MRP1	ABC	ABCC	ABCC1	—	Citalopram, methotrexate, Leukotriene C4
MRP2	ABC	ABCC	ABCC2	S-T-K-F	Olmesartan, methotrexate, etoposide
MRP3	ABC	ABCC	ABCC3	—	Estradiol-17β-glucuronide
MRP4	ABC	ABCC	ABCC4	E-T-A-L	Adefovir, topotecan, methotrexate
MRP7	ABC	ABCC	ABCC10	D-T-R-L	Docetaxel, paclitaxel, viscristine, vinblastine