TABLE 3.

NHERF-dependent regulation of drug transporter function

Uppercase denotes human genes or gene products and lowercase denotes rodent genes or gene products.

Transporter	NHERF Isoform	Experimental Model	Substrate	Transporter Function	Reference
OCTN2	NHERF3 NHERF4	HEK293	Carnitine	Increase	Kato et al., 2005
					Watanabe et al., 2006
Octn2	Nherf3	Nherf3−/− mice	Carnitine	Decrease	Sugiura et al., 2008
OAT4	NHERF1 NHERF3	HEK293	Estrone-3-sulfate	Increase	Miyazaki et al., 2005
		LLC-PK1			Zhou et al., 2008
URAT1	NHERF3	HEK293	Urate	Increase	Anzai et al., 2004
OATP1A2	NHERF1 NHERF3	HEK293	Estrone-3-sulfate	Increase	Zheng et al., 2014
Oatp1a1	Nherf3	Nherf3−/− mice	Estrone-3-sulfate	Increase	Sugiura et al., 2010
PEPT2	NHERF2	Xenopus oocytes	Gly-Gly	Increase	Boehmer et al., 2008
PEPT2	NHERF3	HEK293	Gly-Sar	Increase	Noshiro et al., 2006
					Sugiura et al., 2006
Pept1	Nherf3	Nherf3−/− mice	Cephalexin	Decrease	Sugiura et al., 2008
MRP2	NHERF1	WIF-B	CMFDA	Increase	Karvar et al., 2014
MRP4	NHERF1	HeLa	6-Mercaptopurine, 9-[2-(phosphonylmethoxy) ethyl]-adenine	Decrease	Hoque and Cole, 2008
MRP4	NHERF3	HEK293	Adefovir	Increase	Park et al., 2014
Mrp4	Nherf3	Nherf3−/− mice	Adefovir	Decrease	Park et al., 2014
Bcrp	Nherf3	Nherf3−/−	Cimetidine	Decrease	Shimizu et al., 2011

CMFDA, 5-chloromethylfluorescein diacetate.