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. 2015 Jul;146(1):15–36. doi: 10.1085/jgp.201411333

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© 2015 Gonzalez-Gutierrez and Grosman

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Figure 6. — Lidocaine effects on ELIC. (A) Macroscopic current response to 5-s pulses of 10 mM cysteamine in the continuous presence of 5 mM lidocaine recorded at –80 mV in the outside-out configuration. The trace shown is the average of 25 consecutive responses recorded from a representative patch. The solutions flowing through the two barrels of the perfusion tubing were (in mM) 142 KCl, 5.4 NaCl, 1.8 CaCl₂, 1.7 MgCl₂, 5 lidocaine, and 10 HEPES/KOH, pH 7.4 with or without cysteamine. In the schematic representation of the theta-tubing perfusion, arrows indicate the application of lidocaine. (B) Single-channel inward currents elicited by 10 mM cysteamine recorded at –80 mV in the absence (top) or presence (bottom) of 5 mM lidocaine in the outside-out configuration; openings are downward deflections. The external solution was (in mM) 142 KCl, 5.4 NaCl, 1.8 CaCl₂, 1.7 MgCl₂, 10 cysteamine, and 10 HEPES/KOH, pH 7.4, with or without lidocaine.