Table 1.

Effect of quaternary-ammonium cations and lidocaine on the time course of current decay upon sustained exposure to agonist

Channel	Conditions	τdecay		P-value	Number of patches
		(mean ± SE; ms)	(range; ms)
Wild-type nAChR	Control	37.0 ± 8.8	16.7–63.7	0.37	6
	0.5 mM TEA+	41.2 ± 10.5	23.9–74.6
Wild-type nAChR	Control	48.9 ± 6.8	22.8–61.9	0.11	6
	5 mM TEA+	59.5 ± 5.5	42.3–73.8
Wild-type nAChR	Control	59.8 ± 3.7	51.9–67.1	7.6 × 10−7	4
	0.5 mM lidocaine	0.60 ± 0.07	0.45–0.71
Wild-type GLIC	Control	2,197 ± 950	154–3,928	0.34	6
	5 mM TEA+	1,749 ± 737	146–4,057
Wild-type GLIC	Control	2,072 ± 452	195–5,360	4.3 × 10−3	12
	0.5 mM lidocaine	698 ± 208	36.7–2,045
Wild-type ELIC	Control	4,533 ± 584	2,397–8,026	–	9
	50 mM TEA+	5,353 ± 988	2,443–10,324	0.22	8
	5 mM TEA+ (pipette)	5,370 ± 531	3,979–6,677	0.16	5
	5 mM lidocaine	unmeasurably slow	–	–	14
	50 mM TMA+	4,726 ± 782	1,608–7,725	0.84	9
L9′A + F16′L ELIC	Control	unmeasurably slow	–	–	17
	50 mM TEA+	unmeasurably slow	–	–	7
	50 mM TMA+	unmeasurably slow	–	–	11