Figure 2.

Simulated and experimental V_m and sarcoplasmic Ca concentration as functions of intramural pressure. (A) V_exp (red squares) are the means over 30 s of the observed V_ms after steady-state responses to the indicated intramural pressures were reached, recorded in rat cerebral arteries (Knot and Nelson, 1998). <V_m> (black circles) are the means of V_m over the last 50 s of a 300-s simulation with the normal parameter set (Table S6). In the simulations, the indicated intramural pressures were applied starting at 10 s. (B) Ca_exp (red squares) are the mean Ca concentrations recorded under the conditions in A, and <Ca_in> (black circles) are the means of Ca_in calculated as in A. Error bars represent standard deviations of the experimental data.