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. 2015 Jul;146(1):79–96. doi: 10.1085/jgp.201511380

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© 2015 Karlin

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Figure 6. — Effects of α-adreneric agonist (αA) and ATP on <V_m> and <Ca_in> at 60 mm Hg. (A) <V_m> and (B) <Ca_in> are the means over the last 50 s of a 300-s simulation computed with normal parameters. αA alone (red symbols) or αA and ATP together at the same concentration (black symbols) were added either steadily from t = 40–300 s (C; dashed line) or in pulses from t = 100–300 s (C; solid line). Pulses were on for 1 s and were off for 1.5 s (0.4 Hz), 4 s (0.2 Hz), or 9 s (0.1 Hz). The rate constant for both the rise and fall of a pulse was 2/s. (C) Nominally 1-µM pulses at 0.2 Hz and (inset) two cycles on expanded scale (solid line) are shown, at a steady application of 1 µM (dashed line).