Table 3. Meta-analysis of the MMP3 gene -1171 5A/6A polymorphism (rs35068180) on periodontitis risk.
| Variables | N (Case/Control) | 6A allele vs. 5A allele |
5A/6A vs. 5A/5A |
6A/6A vs.5A/5A |
5A/6A + 6A/6A vs.5A/5A |
6A/6A vs. 5A/5A + 5A/6A |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Phet, I2 (%) | OR (95% CI) | Phet, I2 (%) | OR (95% CI) | Phet, I2 (%) | OR (95% CI) | Phet, I2 (%) | OR (95% CI) | Phet, I2 (%) | ||
| All | 7 (1213/1831) | 0.70 (0.62, 0.80) | 0.315, 15.0 | 0.50 (0.39, 0.65) | 0.221, 31.9 | 0.42 (0.25, 0.69) | 0.265, 24.4 | 0.49 (0.38, 0.62) | 0.238, 29.1 | 0.74 (0.53, 1.02) | 0.539, 0.0 |
| HWE | 4 (721/946) | 0.80 (0.67, 0.96) | 0.655, 0.0 | 1.58 (0.40, 6.22) | — | 1.30 (0.34, 4.94) | — | 1.37 (0.36, 5.20) | — | 0.85 (0.54, 1.33) | — |
| Type of periodontitis | |||||||||||
| CP | 7 (1004/1831) | 0.72 (0.63, 0.82) | 0.163, 34.8 | 0.50 (0.39, 0.64) | 0.345, 9.6 | 0.41 (0.25, 0.68) | 0.336, 11.3 | 0.48 (0.38, 0.62) | 0.317, 14.9 | 0.77 (0.56, 1.07) | 0.438, 0.0 |
| AgP (Asian) | 2 (209/445) | 0.66 (0.48, 0.91) | 0.945, 0.0 | 4.09 (0.21, 80.21) | — | 1.84 (0.10, 35.43) | — | 2.44 (0.13, 46.28) | — | 0.49 (0.24, 1.04) | — |
| Ethnicity | |||||||||||
| Asian | 4 (963/1227) | 0.68 (0.58, 0.80) | 0.149, 43.7 | 0.52 (0.40, 0.68) | 0.198, 38.2 | 0.45 (0.25, 0.81) | 0.173, 42.9 | 0.51 (0.39, 0.66) | 0.202, 37.4 | 0.71 (0.49, 1.03) | 0.357, 2.9 |
| Asian&CP | 4 (754/1227) | 0.73 (0.55, 0.96) | 0.052, 61.2 | 0.52 (0.40, 0.68) | 0.333, 9.0 | 0.44 (0.24, 0.79) | 0.226, 32.8 | 0.50 (0.39, 0.65) | 0.284, 20.6 | 0.75 (0.52, 1.10) | 0.260, 25.7 |
| Caucasian (CP) | 1 (67/202) | 0.66 (0.44, 0.97) | — | — | — | — | — | — | — | ||
| Brazilian Mixed (CP) | 2 (183/402) | 0.80 (0.62, 1.04) | 0.477, 0.0 | 0.31 (0.13, 0.77) | — | 0.32 (0.12, 0.89) | — | 0.31 (0.13, 0.76) | — | 0.83 (0.42, 1.64) | — |
| Smoke | |||||||||||
| Non-smokers | 3 (612/495) | 0.73 (0.60, 0.88) | 0.414, 0.0 | 0.54 (0.39, 0.75) | 0.151, 47.1 | 0.50 (0.28, 0.89) | 0.260, 25.8 | 0.53 (0.39, 0.73) | 0.189, 40.0 | 0.80 (0.57, 1.13) | 0.825, 0.0 |
N, Number of comparisons; OR, odds ratio; 95% CI, 95% confidence interval; CP, chronic periodontitis; AgP, aggressive periodontitis.