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. 2015 Jun 8;112(25):7821–7826. doi: 10.1073/pnas.1509744112

Fig. 4.

Fig. 4.

SF1 helicases partially rescue TDP43-mediated neurodegeneration. (A) hUPF1 had no effect on the survival of control neurons expressing EGFP alone. n = 862–893 neurons per genotype. (B) Ex1-Htt-97Q increased neuronal risk of death, regardless of hUPF1 expression. n = 197–266 neurons per genotype. (C) hUPF1 expression also failed to improve survival in cells expressing SOD1(G85R). n = 253–1028 neurons per genotype. SF1 helicases were safe in control neurons (D), but none prevent cell death due to TDP43(WT) overexpression (E). In contrast, IGHMBP2 and MOV10 mitigated TDP43(A315T)-mediated toxicity (F). *P < 0.02, ns, not significant, by Cox hazards analysis. In D–F, n = 145–198 neurons per genotype. Results were pooled from eight wells per condition, performed in triplicate.