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Effect of hUPF1 on exogenous TDP43 and FUS. The percentage of cells exhibiting cytoplasmic TDP43-EGFP (A) or FUS-EGFP (D) was unchanged by expression of hUPF1. Likewise, the total levels of TDP43(WT)-EGFP (B), TDP43(A315T)-EGFP (C), FUS(WT)-EGFP (E), and FUS(P525L)-EGFP (F) were unaffected by hUPF1 expression. Data were pooled from eight wells per condition, in triplicate. For A–C, n = 319–386 neurons per genotype; for D–F, n = 98–112 neurons per genotype.
