Fig. 1.
Effect of unconsciousness induced by ketamine (A−C, 120 mg/kg, i.p.) or ethanol (D−F, 3.5 g/kg, i.p.) on EEG spectrum in CaV3.1 KO and WT mice. Reduced low-frequency (delta) and increased high-frequency oscillations (beta and/or gamma) were observed both in absolute and relative value of spectral power of KO, compared with WT. (A and D) Representative EEG recordings from FCx and PCx. (B and E) Mean absolute power of accumulated several frequency bands in EEG recordings from FCx and PCx. (C and F) Relative power of spectral distribution. Frequency bands are represented as follows: delta (δ), 1–4 Hz; theta (θ), 4–8 Hz; alpha (α), 8–12 Hz; beta (β), 12–25 Hz; and gamma (γ), 25–50 Hz. Statistically significant differences marked as *P < 0.05, **P < 0.01, and ***P < 0.001, one-way ANOVA.