Fig. 5.

FCx-MD functional connectivity by cross-bispectral coherence. (A and B) Averaged cross-bispectral coherence between MD and FCx during unconsciousness induced by ketamine. The value of bicoherence peak was lower in KO than WT mice. Note that the heterogeneous pairs of biphasic frequencies of broad frequency bands were observed only in KO mice, particularly in the cross-bispectral coherence from MD to FCx (see the scattered pattern of peak bicoherence). (C and D) Same as in A and B under ethanol-induced unconsciousness. The significantly lowered cross-bispectral coherence in low-frequency band and the heterogeneous pairs of bicoherence in other frequency bands were also observed in KO mice.