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. 2015 Jun 8;112(25):7773–7778. doi: 10.1073/pnas.1424104112

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Fig. 6. — Characterization of DN tumor precursor cells in ThPOK^const mice. (A) FACS analysis of gated TCR⁻ DN (CD4⁻CD8⁻) thymocytes from 5-wk-old ThPOK^const mice and WT littermates. Note the relative increase in the DN4 (CD44⁻CD25⁻) fraction in all ThPOK^const mice, and the appearance of CD44^INT cells, which also express variable levels of CD25, in a subset of ThPOK^const animals (Bottom row; CD44^INT population is outlined in red). (B) A total of 25–100 × 10³ sorted DN thymocytes from indicated mice were transferred into sublethally irradiated Rag2^−/− recipient mice, and PBLs were analyzed by FACS for CD4 and CD8 expression at indicated times.