Table 1.
Metabolic data in all experimental groups of renal failure (RF), with (DNX) or without (INN) renal denervation, and control rats.
| Group | Day 1 | Day 8 | |
|---|---|---|---|
| Body Weight (g) | Control INN | 272 ± 8 | 286 ± 7 |
| RF INN | 268 ± 6 | 248 ± 12 | |
| RF DNX | 271 ± 5 | 281 ± 7*# | |
| UNaV (μMh−1kg−1) | Control INN | 157 ± 5 | 164 ± 7 |
| RF INN | 157 ± 4 | 154 ± 6 | |
| RF DNX | 155 ± 5 | 159 ± 5 | |
| FENa(%) | Control INN | 0.9 ± 0.11 | 0.8 ± 0.10 |
| RF INN | 0.7 ± 0.02# | 2.5 ± 0.36*# | |
| RF DNX | 1.12 ± 0.21 | 4.86 ± 0.22 | |
| NER (ngmL−1h−1) | Control INN | 0.037 ± 0.006 | 0.024 ± 0.005 |
| RF INN | 0.053 ± 0.005 | 0.189 ± 0.024*# | |
| RF DNX | 0.045 ± 0.010 | 0.063 ± 0.013 | |
| GFR (mLmin−1kg−1) | Control INN | 2.3 ± 0.2 | 2.0 ± 0.1 |
| RF INN | 2.7 ± 0.3# | 1.1 ± 0.2*# | |
| RF DNX | 4.0 ± 0.2* | 1.4 ± 0.5 | |
| UV (mLh−1kg−1) | Control INN | 1.0 ± 0.1 | 0.5 ± 0.1 |
| RF INN | 1.6 ± 0.3 | 1.8 ± 0.5* | |
| RF DNX | 0.5 ± 0.1 | 0.6 ± 0.2 |
Statistical analysis was performed using Two-Way ANOVA followed by Tukey's post hoc test. Data presented as mean SEM. (Control INN n = 12, RF and RF DNX, n = 8 per group). UNaV, absolute sodium excretion; FENa, fractional excretion of sodium; NER, noradrenaline excretion rate; GFR, glomerular filtration rate (creatinine clearance); UV, urine flow rate.
*
P < 0.05 vs. control INN,
#P < 0.05 vs. RF DNX.