Table 2.
Baseline mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) and baroreflex gain curve parameters.
| Control INN | RF INN | Control DNX | RF DNX | |
|---|---|---|---|---|
| Baseline HR (beats min−1) | 346 ± 27 | 347 ± 13 | 358 ± 18 | 361 ± 20 |
| Baseline MAP (mmHg) | 94 ± 7 | 83 ± 4 | 72 ± 5 | 78 ± 3 |
| Baseline RSNA (mVs−1) | 7 ± 3 | 29 ± 6*# | 4 ± 1 | 2 ± 0.3 |
| A1 (% RSNA) | 98 ± 19 | 43 ± 15* | 103 ± 8 | 98 ± 15 |
| A2 (% RSNA mmHg−1) | 0.14 ± 0.01 | 0.07 ± 0.02*# | 0.11 ± 0.03 | 0.14 ± 0.02 |
| A3 (mmHg) | 94 ± 17 | 138 ± 17*# | 88 ± 8 | 104 ± 6 |
| A4 (% RSNA) | 68 ± 23 | 68 ± 9# | 31 ± 2 | 37 ± 7 |
A1, the range of the curve; A2, the slope or sensitivity of the curve; A3, the mid-point blood pressure; and A4, the minimum point to which the RSNA could be driven in all experimental groups. Renal failure (RF) and control rats, with (DNX) or without (INN) renal denervation. Statistical analysis was performed using Two-Way ANOVA followed by Tukey's post hoc test. Data presented as mean SEM. (n = 12 for control and n = 8 for RF groups).
*
P < 0.05 vs. control INN; *P < 0.005 vs. control
#
P < 0.05 vs. RF DNX.