Table 2.
Breeding statistics for the first generation of each EUCOMM line.
| Line | Strategy (female × male) | # BPs | # litters per BP | Total # pups reported | % Weaned males | Av. litter size | Pre-wean mortality (%) | Genotype % (expected %) |
Genotype by sex (% desired genotype) |
||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Desired | Other | Male | Female | ||||||||
| GOI-1 | |||||||||||
| tm1a | tm1a/wt × wt or wt × tm1a/wt | 10 | 2 | 139 | 61.2 | 5.8 | 5.0 | 54.1 tm1a (50) | 45.9 wt (50) | 58.8 | 46.5 |
| tm1b | tm1a/wt x Cre/Y | 8 | 1–2 | 88 | 0a (52.3) | 7.3 | 1.1 | 36.1 tm1b (25) | 63.9 tm1a or Cre only (75) | n.a. | 36.6 |
| tm1c | Flp/wt x tm1a/wt | 10 | 1–2 | 120 | 57.9 | 6.6 | 16.8 | 26.5 tm1c (25) | 73.5 tm1a or Flp only (75) | 29.5 | 23.1 |
| tm1d | Cre/Cre x tm1c/wt | 7 | 1–2 | 80 | 38.7 | 7.3 | 0 | 34.2 tm1d (50) | 65.8 wt (50) | 32.2 | 35.4 |
| GOI-2 | |||||||||||
| tm1a | tm1a/wt x wt or wt x tm1a/wt | 6 | 1–4 | 64 | 100a (43.7) | 6.4 | 0 | 72.2 tm1a (50) | 27.8 wt (50) | 72.2 | n.a. |
| tm1c | Flp/Flp x tm1a/wt or tm1a/wt x Flp/Flp | 8 | 1 | 54 | 46.3 | 7.7 | 0 | 53.7 tm1c (50) | 46.3 wt (50) | 62.5 | 50 |
| inducible tm1d | tm1c/wt; Flp/wt x MCM/MCM | 4 | 1–3 | 53 | 37.7 | 6.6 | 1.9 | 25.7 tm1d and MCM (25) | 74.3 wt or Flp (75) | 28.6 | 23.8 |
BP, breeding pair.
aIndicates that only one sex was weaned. % of total males is indicated in parentheses.