Table 1.

Gene-Ontology (GO) database search in EcoCyc of the knockout mutants selected in based on the statistically significant results of the parameters evaluated shown in Figure 3

Gene-Ontology-terms	p-valuesa	Matches (mutant strains)
Fermentation	2.22E−08	ldhA//“frdB”//“frmA”//“frdA”//“frdC”
Generation of precursor metabolites and energy	1.58E−07	frdB//“tdcE”//“frdA”//“frdC”//“glgC”//“ldhA”//“frmA”//“fumA”
Energy derivation by oxidation of organic compounds	5.45E−07	frdB//“tdcE”//“frdA”//“frdC”//“glgC”//“ldhA”//“frmA”
Aspartate family amino acid catabolic process	2.02E−05	sucB//“tdcB”//“tdcE”
Bacterial-type flagellum assembly	2.57E−05	frdA//“frdB”//“frdC”
Ethanol metabolic process	5.57E−05	ldhA//“frmA”
Oxidation–reduction process	6.95E−05	gnd//“rpiA”//“frdB”//“tdcE”//“frdA”//“frdC”//“glgC”//“ldhA”//“frmA”
Single-organism metabolic process	9.44E−05	rpiA//“gnd”//“deoB”//“gadB”//“tdcB”//“frdB”//“tdcE”//“frdA”//“frdC”//“glgC”//“frmA”//“cpsG”//“ldhA”//“sucB”//“nanE”
Single-organism catabolic process	1.52E−04	ldhA//“gnd”//“rpiA”//“deoB”//“tdcB”//“sucB”//“tdcE”//“nanE”//“frmA”
Tricarboxylic acid cycle	1.57E−04	fumA//“frdB”//“sucB”
l-threonine catabolic process to propionate	3.86E−04	tdcB//“tdcE”
Anaerobic respiration	4.10E−04	frdB//“tdcE”//“frdA”//“frdC”
Organic substance catabolic process	6.34E−04	frmA//“tdcB”//“sucB”//“tdcE”//“ldhA”//“gnd”//“rpiA”//“nanE”//“deoB”
Glucose catabolic process	6.49E−04	ldhA//“gnd”//“rpiA”
Cell motility	8.04E−04	frdA//“frdB”//“frdC”
Carbohydrate metabolic process	8.48E−04	rpiA//“gnd”//“ldhA”//“glgC”//“cpsG”//“nanE”//“tdcE”
Small molecule metabolic process	8.52E−04	frmA//“cpsG”//“deoB”//“gnd”//“rpiA”//“ldhA”//“gadB”//“tdcB”//“sucB”//“tdcE”//“nanE”
Cellular metabolic process	8.65E−04	deoB//“frdB”//“tdcE”//“frdA”//“frdC”//“frmA”//“gnd”//“rpiA”//“cpsG”//“glgC”//“ldhA”//“gadB”//“tdcB”//“nanE”//“sucB”//“fumA”
Cellular respiration	9.59E−04	frdB//“tdcE”//“frdA”//“frdC”

^aThe matches were found using a P < 0.001 which are denoted as scientific notation (E).