Table 3.

Multivariable-Adjusted Odds Ratios of Intermediate Endpoints Associated With Metabolically At-Risk Overweight/Obesity

	Model 1 (N=362)		Model 2 (N=362)		Model 3 (N=259)
	OR (95% CI)	p value	OR (95% CI)	p value	OR (95% CI)	p value
MetS, ATP criteria	4.48 (1.94,10.35)	<0.001	3.06 (1.28, 7.31)	0.012	5.47 (1.72, 17.35)	0.004
Systemic inflammation (CRP ≥3.0 mg/dL)	1.83 (1.1, 3.03)	0.02	1.24 (0.72, 2.13)	0.44	1.06 (0.56, 2.03)	0.86
NAFLD (PNFI ≥9)	10.03 (4.61 21.80)	<0.001	6.94 (2.49, 19.34)	<0.001	8.66 (2.48, 30.31)	0.001
Microalbuminuria (albumin/creatinine ratio ≥30)	1.95 (0.71, 5.37)	0.20	2.66 (0.91, 7.82)	0.07	1.71 (0.49, 6.04)	0.403

Model 1: adjusted for age, sex and race/ethnicity. Model 2: model 1+adjusted for BMI z-score. Model 3: model 2+adjusted for moderate/vigorous activity. Model 3 includes only participants with valid accelerometer data.

MetS, metabolic syndrome; ATP, the National Cholesterol Education Program's Adult Treatment Panel; CRP, C-reactive protein; NAFLD, nonalcoholic fatty liver disease; PNFI, pediatric NAFLD fibrosis index; PNFI, pediatric NAFLD fibrosis index; OR, odds ratio; CI, confidence interval.