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. 2015 Jun 20;22(18):1633–1645. doi: 10.1089/ars.2014.6078

FIG. 5.

FIG. 5.

IsoLG-PE and its metabolite IsoLG-ETN activate NFκB-luciferase reporter expression in bone marrow-derived macrophages from transgenic NFκB reporter mice (nfkb-BMDM). Results are shown as mean±SEM of all replicates from experiments on a minimum of 3 separate days, n=4–6 independent replicates per day, and normalized to expression in vehicle-treated cells. (A) Effects of IsoLG-PE and PE on NFκB reporter expression activity. Two-way ANOVA, p<0.0001, treatment, p=0.0008 concentration; *p<0.01, Bonferroni's multiple-comparisons test IsoLG-PE versus PE for the same concentration. (B) Effects of IsoLG-ETN and ETN on NFκB reporter expression activity. Two-way ANOVA, p<0.0001, treatment, concentration; *p<0.01, Bonferroni's multiple-comparisons test IsoLG-ETN versus ETN for the same concentration. IsoLG-ETN, isolevuglandin-modified ethanolamine.