Fig 1. Biphasic effect of the TAS2R10 agonist CQ on HASM cell [Ca2+]i mobilization.
(A) Representative dose-response and time course of [Ca2+]i in cells treated with 3 μM histamine and the indicated concentrations of CQ. (B) Biphasic [Ca2+]i response to CQ in HASM concomitantly treated with 3 μM histamine. (C) Inhibitory limb of the [Ca2+] response to CQ in HASM concomitantly treated with 3 μM histamine. (D) Stimulation of [Ca2+] by CQ in HASM. There is no co-treatment with histamine in this experiment. Shown are representative results (mean ± SE of quadruplicates) of 3–5 independent experiments performed.