Table 3.

Assessment of Risk of Bias

			Domain; Risk of Bias*
Study	Sequence Generation	Allocation Concealment	Blinding	Incomplete Data Outcome	Selective Outcome Reporting	Other
Ameer et al. (1983)†21	Unclear	Unclear	Low	Low	Low	Unclear
Pettersson et al. (2005)22	Unclear	Unclear	High	Unclear	Low	Low
Van der Westhuizen et al. (2001)†23	Low	Unclear	Low	Low	Unclear	Low
Brett et al. (2012)24	Low	Unclear	Unclear	Low	Low	Low
Singla et al. (2012)25	Unclear	Unclear	Low	Low	Unclear	Unclear
Fenlon et al. (2013)26	Low	Low	Low	Low	Low	Unclear

^*Risk of bias was categorized as low, high, or unclear.

^†Open-label study with low risk of bias because of objective pharmacokinetic outcomes.