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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Genet. 2015 Jun 1;47(7):766–775. doi: 10.1038/ng.3321

Figure 1. Generation of an allelic series of miR-17~92 mutant mice.

Figure 1

(a) Schematic of the miR-17~92 cluster. Sequence of the mature miRNAs is shown below, with the seed (nucleotides 2–7) in bold. Arrow: direction of transcription. (b) Top, Schematic of the targeting strategy, using the miR-17~92Δ19 allele as an example. DTA, diphtheria toxin gene. Bottom, Schematic of the miRNAs expressed by each allele. (c) Heat map showing miRNA expression (detected by RT-qPCR) in tails from homozygous mice relative to wild type controls (n = 3).