Table 1.
Baseline Study Sample Characteristics by Tertiles of mGFR
| Characteristic | Overall (N=250) |
Low: mGFR 22- 114 (n=84) |
Middle: mGFR 115- 146 (n=83) |
High: mGFR 147- 235 (n=83) |
|---|---|---|---|---|
| Age at sample collection (y) | 42.4 ±10.5 | 48.4 ±9.6 | 42.5 ±9.8 | 36.1 ±8.5 |
| Female Sex | 173 (69.2%) | 56 (66.7%) | 53 (63.9%) | 64 (77.1%) |
| BMI (kg/m2) | 35.4 (8.5) | 36.6 (9.5) | 34.2 (7.2) | 35.5 (8.6) |
| Age at diabetes diagnosis (y) | 31.2 (9.5) | 35.4 (9.0) | 32.6 (8.6) | 25.6 (8.1) |
| Duration of diabetes (y) | 11.2 (6.6) | 13.0 (7.1) | 9.9 (6.0) | 10.5 (6.3) |
| Hemoglobin Alc | 9.4 (2.3) | 8.9 (2.3) | 8.9 (2.3) | 10.2 (2.2) |
| Insulin use | 62 (24.8%) | 25 (29.8%) | 17 (20.5%) | 20 (24.1%) |
| Oral hypoglycemic medicine use | 110 (44.0%) | 46 (54.8%) | 36 (43.4%) | 28 (33.7%) |
| Systolic BP (mm Hg) | 120 (15) | 125 (15) | 119 (15) | 116 (13) |
| Diastolic BP (mm Hg) | 75 (9) | 77 (10) | 75 (9) | 75 (8) |
| Antihypertensive medicine use | 32 (12.8%) | 16 (19.0%) | 9 (10.8%) | 7 (8.4%) |
| Hypertension | 54 (21.6%) | 27 (32.1%) | 17 (20.5%) | 10 (12.0%) |
| Serum cholesterol (mg/dL) | 172 (42) | 171 (39) | 166 (39) | 179 (46) |
| Serum triglycerides (mg/dL) | 136 [101-216] | 131 [105-214] | 125 [98-192] | 158 [106-230] |
| Urinary ACR (mg/g) | 37 [14-169] | 48 [13-718] | 30 [11-128] | 34 [17-89] |
| Albuminuria status | ||||
| Normoalbuminuria | 113 (45.2%) | 34 (40.5%) | 42 (50.6%) | 37 (44.6%) |
| Moderately elevated | 91 (36.4%) | 25 (29.8%) | 31 (37.3%) | 35 (42.2%) |
| Severely elevated | 46 (18.4%) | 25 (29.8%) | 10 (12.0%) | 11 (13.3%) |
| mGFR (mL/min) | 149 (45) | 104 (29) | 148 (19) | 195 (26) |
| mGFR (mL/min/ 1.73m2) | 129 (37) | 89 (20) | 129 (9) | 169 (20) |
| Creatinine (mg/dL) | 0.58 (0.24) | 0.73 (0.34) | 0.54 (0.10) | 0.47 (0.12) |
| eGFRcr (mL/min/1.73m2) | 118 (20) | 102 (21) | 121 (10) | 132 (14) |
| Cystatin C (mg/L) | 0.83 (0.25) | 1.05 (0.31) | 0.78 (0.11) | 0.68 (0.12) |
| eGFRcys (mL/min/1.73 m2) | 101 (23) | 79 (22) | 107 (13) | 119 (14) |
| B2M (mg/L) | 2.10 (0.70) | 2.57 (0.89) | 1.99 (0.41) | 1.73 (0.33) |
| BTP (mg/L) | 0.47 (0.24) | 0.61 (0.31) | 0.43 (0.17) | 0.36 (0.15) |
Note: mGFRs expressed in mL/min/1.73 m2. Values for categorical variables are given as number (percentage); values for continuous variables are given as mean ± standard deviation or median [interquartile range]. Conversion factors for units: creatinine in mg/dL to μmol/L, ×88.4; cholesterol in mg/dL to mmol/L, ×0.02586; triglycerides in mg/dL to mmol/L, ×0.01129.
Abbreviations: BP, blood pressure; B2M, β2-microglobulin; BTP, P-trace protein;; BMI, body mass index; eGFRcr, creatinine-based estimated glomerular filtration rate; eGFRcys, cystatin C–based estimated glomerular filtration rate; mGFR, measured glomerular filtration rate; ACR, albumin-creatinine ratio.