Table 3.

Adjusted Hazard Ratios for Incident ESRD and All-Cause Mortality by Filtration Marker

	Age-sex		Multivariablea		Multivariablea + eGFRcr		Multivariablea + mGFR
	HRb (95% CI)	P	HRb (95% CI)	P	HRb (95% CI)	P	HRb (95% CI)	P
ESRD (n=69 events; median follow-up, 13.5 y)
mGFR	1.61 (1.07, 2.43)	0.02	2.01 (1.31, 3.11)	0.002	1.55 (0.90, 2.69)	0.1	-d	-
eGFRcr	1.82 (1.33, 2.49)	<0.001	1.75 (1.26, 2.45)	0.001	-c	-	1.40 (0.91, 2.17)	0.1
eGFRcys	2.20 (1.55, 3.12)	<0.001	2.86 (1.94, 4.22)	<0.001	3.37 (1.94, 5.87)	<0.001	3.28 (1.90, 5.67)	<0.001
1/BTP	1.68 (1.15, 2.44)	0.01	1.71 (1.14, 2.57)	0.01	1.48 (0.99, 2.23)	0.06	1.53 (1.01, 2.30)	0.04
1/B2M	1.70 (1.19, 2.44)	0.004	1.87 (1.28, 2.72)	0.001	1.53 (0.95, 2.46)	0.08	1.54 (0.98, 2.42)	0.06
All-Cause Mortality (n=95 events; median follow-up, 13.9 y)
mGFR	1.16 (0.81, 1.66)	0.4	1.17 (0.80, 1.70)	0.4	1.01 (0.62, 1.65)	0.9	-d	-
eGFRcr	1.28 (0.97, 1.70)	0.08	1.22 (0.89, 1.67)	0.2	-c	-	1.21 (0.80, 1.82)	0.4
eGFRcys	1.44 (1.06, 1.94)	0.02	1.44 (1.04, 1.98)	0.03	1.54 (0.99, 2.41)	0.06	1.68 (1.07, 2.64)	0.02
1/BTP	1.05 (0.84, 1.32)	0.6	1.02 (0.81, 1.28)	0.9	0.98 (0.79, 1.23)	0.9	1.00 (0.80, 1.26)	0.9
1/B2M	1.78 (1.28, 2.47)	0.001	1.78 (1.25, 2.53)	0.001	2.02 (1.31, 3.11)	0.001	2.12 (1.38, 3.26)	0.001

Abbreviations: B2M, β₂-microglobulin; BTP, β-trace protein; CI, confidence interval; eGFR_cr, creatinine-based estimated glomerular filtration rate; eGFR_cys, cystatin C–based estimated glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; mGFR, measured glomerular filtration rate.

^aAdjusted for age, sex, duration of diabetes, hemoglobin A1c, hypertension, total cholesterol, and natural logarithm-transformed urinary albumin-creatinine ratio.

^bExpressed per interquartile decrease in each marker.

^cNo HR reported because eGFR_cr already in model for this row.

^dNo HR reported because mGFR already in model for this row.