. Author manuscript; available in PMC: 2016 Jul 1.

Published in final edited form as: Am J Kidney Dis. 2015 Mar 12;66(1):75–83. doi: 10.1053/j.ajkd.2015.01.013

Table 4.

C statistics, Likelihood Ratio Test P-Values, and the 10-Year RIDI and Continuous NRI for Models with and without Biomarker Information

Outcome	Model	C statistic without Biomarker^*	C statistic with Biomarker^*	Difference in C statistic (95% CI)	Likelihood Ratio Test P-Value	RIDI (95% CI)	Continuous NRI (95% CI)
Base Model: mGFR+eGFR_cys With Multivariable^a Adjustment
ESRD	+ 1/BTP	0.843	0.842	−0.001 (−0.006, 0.004)	0.4	−0.000 (−0.020, 0.019)	−0.050 (−0.390, 0.290)
	+ 1/B2M	0.843	0.843	0.000 (−0.004, 0.004)	0.4	0.002 (−0.019, 0.024)	0.189 (−0.156, 0.533)
All-cause Mortality	+ 1/BTP	0.724	0.724	−0.000 (−0.005, 0.005)	0.7	0.003 (−0.006, 0.013)	0.327 (−0.027, 0.681)
	+ 1/B2M	0.724	0.735	0.011 (−0.008, 0.030)	0.007	0.116 (0.007, 0.224)	0.186 (−0.176, 0.549)
Base Model: eGFR_cr+eGFR_cys With Multivariable^a Adjustment
ESRD	+ 1/BTP	0.845	0.844	−0.001 (−0.007, 0.005)	0.4	−0.003 (−0.025, 0.018)	−0.029 (−0.371, 0.312)
	+ 1/B2M	0.845	0.845	0.000 (−0.004, 0.005)	0.4	−0.000 (−0.021, 0.021)	0.177 (−0.171, 0.524)
All-cause Mortality	+ 1/BTP	0.719	0.719	−0.000 (−0.004, 0.004)	0.7	0.003 (−0.007, 0.014)	0.011 (−0.335, 0.358)
	+ 1/B2M	0.719	0.733	0.014 (−0.004, 0.033)	0.007	0.108 (0.002, 0.215)	0.159 (−0.198, 0.515)

Abbreviations: B2M, β₂-microglobulin; BTP, β-trace protein; CI, confidence interval; eGFR_cr, creatinine-based estimated glomerular filtration rate; eGFR_cys, cystatin C–based estimated glomerular filtration rate; ESRD, end-stage renal disease; HR, hazard ratio; RIDI, relative integrated discrimination improvement; mGFR, measured glomerular filtration rate; NRI, net reclassification improvement.

B2M or BTP.

Adjusted for age, sex, hypertension, total cholesterol, natural logarithm-transformed urinary ACR, hemoglobin A1c, and duration of diabetes.