Table 3.
Kidney function at 6, 12, 24, and 36 months after kidney donation.
| Test | Group | Visit (Time after donation) | P-Valuesa | |||||
|---|---|---|---|---|---|---|---|---|
| 6 Mo | 12 Mo | 24 Mo | 36 Mo | Donors vs Controlsb |
Visitc | Interactiond | ||
| mGFR (mL/min) | Controls | 104.9±20.2 (194) |
105.4±20.2 (189) |
104.5±19.7 (177) |
104.1 ±20.7 (168) |
<0.001 | 0.04 | <0.001 |
| Donors | 74.3±12.9 (193) |
74.5±13.3 (192) |
76.3±13.9 (182) |
77.5± 14.0 (180) |
||||
| mGFR (mL/min/1.73 m2) | Controls | 94.6±15.1 (194) |
94.8±15.3 (189) |
94.1 ±14.9 (177) |
93.2±14.6 (168) |
<0.001 | 0.4 | <0.001 |
| Donors | 67.6±10.1 (193) |
67.5±10.4 (192) |
69.4±10.5 (182) |
69.7±10.1 (180) |
||||
| Scr (mg/dL) | Controls | 0.80±0.17 (198) |
0.80±0.16 (193) |
0.80±0.15 (182) |
0.80±0.14 (173) |
<0.001 | <0.001 | <0.001 |
| Donors | 1.16±0.22 (199) |
1.15±0.22 (196) |
1.12±0.22 (185) |
1.10±0.23 (182) |
||||
| eGFRcr (mL/min/1.73 m2) | Controls | 99.1±16.0 (198) |
98.3±16.7 (193) |
97.9±15.2 (182) |
97.5± 14.6 (173) |
<0.001 | 0.007 | <0.001 |
| Donors | 65.5±13.1 (199) |
66.5±13.3 (196) |
68.0±14.3 (185) |
69.3± 14.6 (182) |
||||
| CysC (mg/dL) | Controls | 0.81±0.14 (198) |
0.81±0.13 (193) |
0.80±0.14 (182) |
0.81±0.13 (173) |
<0.001 | <0.001 | 0.008 |
| Donors | 1.11 ±0.17 (199) |
1.08±0.15 (196) |
1.07±0.15 (185) |
1.06±0.16 (182) |
||||
| eGFRcys (mL/min/1.73 m2) | Controls | 102.3±17.5 (198) |
102.3±15.9 (193) |
103.3±17.2 (182) |
101.6±16.5 (173) |
<0.001 | 0.02 | 0.01 |
| Donors | 71.6±15.3 (199) |
73.6± 14.8 (196) |
74.5±15.2 (185) |
75.2±16.3 (182) |
||||
| eGFRcr-cys (mL/min/1.73 m2) | Controls | 101.3±16.8 (198) |
100.7±15.3 (193) |
101.5±16.0 (182) |
100.3±15.3 (173) |
<0.001 | <0.001 | <0.001 |
| Donors | 67.4±12.6 (198) |
68.8±12.5 (196) |
70.1 ±13.1 (185) |
71.2±14.1 (182) |
||||
| Urea nitrogen (mg/dL) | Controls | 14.5±4.0 (198) |
14.5±4.1 (193) |
14.6±4.1 (182) |
14.5±3.7 (173) |
<0.001 | 0.5 | 0.7 |
| Donors | 18.0±4.4 (200) |
17.5±4.0 (196) |
17.7±4.4 (185) |
17.7±4.5 (182) |
||||
| Urine PCR (g/g) | Controls | 62 [50–128] (195) |
70 [50–106] (193) |
61 [49–100] (178) |
63 [47–122] (169) |
0.6e | 0.3e | 0.7e |
| Donors | 70 [50–116] (201) |
70 [50–116] (197) |
60 [46–114] (182) |
60 [48–111] (181) |
||||
| Urine ACR (mg/g) | Controls | 4.7 [3.4–7.1] (193) |
5.0 [3.5–7.7] (191) |
5.1 [3.6–7.2] (178) |
4.7 [3.4–7.3] (168) |
<0.001e | 0.002e | 0.001e |
| Donors | 3.6 [2.4–5.8] (198) |
3.5[2.4–6.1] (195) |
3.8 [2.8–6.6] (182) |
4.2 [2.7–7.1] (180) |
||||
Note: Values are given as mean ± standard deviation or median [interquartile range] (number sampled). Conversion factors for units: Scr in mg/dL to µmol/L, × 88.4; urea nitrogen in mg/dL to mmol/L, × 0.357.
Abbreviations and definitions: CysC, cystatin C; eGFRcr, estimated glomerular filtration rate calculated by Chronic Kidney Disease Epidemiology Collaboration creatinine equation; eGFRcr-cys, estimated glomerular filtration rate calculated by Chronic Kidney Disease Epidemiology Collaboration creatinine-cystatin C equation; eGFRcys, estimated glomerular filtration rate calculated by Chronic Kidney Disease Epidemiology Collaboration cystatin C equation; mGFR, measured glomerular filtration rate by iohexol plasma clearance; Scr, serum creatinine; ACR, albumin-creatinine ratio; PCR, protein-creatinine ratio.
Analysis of variance with repeated measures. Each variable was analyzed separately and no adjustment was made for multiple comparisons. Values not normally distributed were logarithmically transformed before analysis.
Donors versus controls P values test overall differences between donors and controls.
Visit P values test differences between the 4 visits.
Interaction P values test the interaction between donors versus controls and between visits.
Based on logarithmically transformed values.