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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Heart Rhythm. 2015 Mar 23;12(7):1599–1610. doi: 10.1016/j.hrthm.2015.03.043

Figure 3.

Figure 3

Effect of KN-93 on the development of spontaneous Ca2+ aftertransients (ATs) as well as aftercontractions (ACs) in WT and JKO cardiomyocytes, under stress conditions (3 Hz + 1 μM iso) A–B) Percentage of WT and JKO cells that developed aftertransients (A) and aftercontractions (B) at 3 Hz, in the presence of 1μM isoproterenol. The cells were either control treated (DMSO), or pretreated for 30 min with 1 μM KN-93. Data shown are the average ±SEM of n=50 cells from 5 different hearts (N=5). Symbols represent statistically significant differences (p<0.05) between WT/JKO (*) and JKO/JKO+KN-93 (†). C–D) Representative traces of Ca2+ Aftertransients (C) (ATs) and Aftercontractions (D) in WT and JKO cardiomyocytes.