. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Clin Psychopharmacol. 2015 Aug;35(4):374–381. doi: 10.1097/JCP.0000000000000345

Table 3.

Minocycline - Placebo Difference Effect Sizes for MATRICS Cognitive Battery Domains

	Minocycline (N=27)		Placebo (N=23)		Effect Size	Mean ± SE, p
	Weeks	Mean ± SD	Weeks	Mean ± SD	Effect Size	Mean ± SE, p
Composite Score	0	20.0 ± 13.1	0	27.7 ± 12.9	0.08	0.98 ± 1.69, p=0.56
Composite Score	10	22.3 ± 12.9	10	27.3 ± 13.8	0.08	0.98 ± 1.69, p=0.56
Attention/Vigilance	0	31.8 ± 13.1	0	35.0 ± 13.2	−0.08	−0.98 ± 2.07, p=0.64
Attention/Vigilance	10	32.6 ± 14.1	10	35.9 ± 13.2	−0.08	−0.98 ± 2.07, p=0.64
Processing Speed	0	29.5 ± 12.4	0	34.8 ± 12.8	0.09	1.17 ± 1.86, p=0.53
Processing Speed	10	31.6 ± 12.4	10	34.3 ± 11.4	0.09	1.17 ± 1.86, p=0.53
Problem Solving	0	37.0 ± 10.5	0	42.6 ± 8.1	0.004	0.04 ± 1.90, p=0.98
Problem Solving	10	38.0 ± 10.6	10	42.0 ± 9.5	0.004	0.04 ± 1.90, p=0.98
Social Cognition	0	31.7 ± 13.6	0	34.5 ± 10.3	−0.1	−1.17 ± 2.84, p=0.68
Social Cognition	10	33.4 ± 14.3	10	36.6 ± 11.6	−0.1	−1.17 ± 2.84, p=0.68
Verbal Learning	0	32.3 ± 6.3	0	34.3 ± 7.2	−0.35	−2.39 ± 1.79, p=0.19
Verbal Learning	10	31.8 ± 7.2	10	35.6± 11.0	−0.35	−2.39 ± 1.79, p=0.19
Visual Learning	0	27.7 ± 11.9	0	34.4 ± 13.2	−0.11	−1.33 ± 2.35, p=0.57
Visual Learning	10	27.8 ± 12.4	10	33.9 ± 11.3	−0.11	−1.33 ± 2.35, p=0.57
Working Memory	0	30.4 ± 11.6	0	35.1 ± 11.7	0.41	4.81 ± 1.82, p=0.01
Working Memory	10	35.6 ± 10.7	10	34.2 ± 12.2	0.41	4.81 ± 1.82, p=0.01