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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Genet. 2015 May 18;47(7):822–826. doi: 10.1038/ng.3292

Fig. 2. Offspring of older fathers harbor a higher percentage of de novo mutations in genes.

Fig. 2

Top panel: the percentage of de novo mutations within genic regions as a function of paternal age at conception (p = 0.0085, slope = 0.26% per year of paternal age).

Bottom panel: the number of genic (red) and intergenic (blue) de novo mutations in offspring (on a logarithmic scale) as a function of paternal age. The red line shows the least-square regression for genic mutations (p < 2 × 10−16), the blue line for intergenic mutations (p = 3.7 × 10−14). The steeper slope of the regression line for genic mutations indicates a faster relative increase in genic than intergenic mutations with paternal age.