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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Nat Genet. 2015 Jun 1;47(7):776–783. doi: 10.1038/ng.3324

Figure 2. Genome-wide identification of dysregulated mRNAs in TrbpcKO hearts.

Figure 2

a) qRT-PCR of Myh6 and Myh7 mRNA levels in TrbpcKO and control hearts at 2 weeks (n = 3) and 1 month (n = 6).

b) Hierarchical clustering heatmap of 351 upregulated and 395 downregulated transcripts from 2-week old TrbpcKO and control hearts. Multiple fast-twitch (red) and slow-twitch (blue) myofiber genes and Hopx, Sox6 genes are marked.

c) The top 5 functional categories from Gene Ontology (GO, Molecular Function) analyses of dysregulated genes in TrbpcKO hearts.

d) The top 5 categories from KEGG pathway analysis of dysregulated genes in TrbpcKO hearts.

e) qRT-PCR of fast-twitch myofiber genes in 2-week old TrbpcKO hearts. n = 3.

f) qRT-PCR of slow-twitch myofiber genes in 2-week old TrbpcKO hearts. n = 3. Values are expressed as the mean ± SD. NS: not significant, *: P<0.05, **: P<0.01.