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. Author manuscript; available in PMC: 2015 Jun 30.
Published in final edited form as: Nature. 2008 Aug 17;455(7213):679–683. doi: 10.1038/nature07260

Figure 3. Inhibition of endogenous Myc suppresses proliferation in skin, testis and GI tract.

Figure 3

a, Anti-Ki67-stained sections of epidermis from 4-week doxycycline-treated TRE-Omomyc;CMVrtTA mice and CMVrtTA single transgenic controls. b, Anti-Ki67-stained sections of testis from 4-week doxycycline-treated TRE-Omomyc;CMVrtTA mice show reduced proliferation in seminiferous tubules of doxycycline-treated TRE-Omomyc; CMVrtTA mice compared with Omomyc-negative controls. c, Haematoxylin-and-eosin-stained small intestine sections show blunted villi in TRE-Omomyc;CMVrtTA mice treated for 4 weeks with doxycycline (TRE-Omomyc;CMVrtTA +doxycycline) compared with intestine from untreated TRE-Omomyc;CMVrtTA and doxycycline-treated CMVrtTA single transgenic (CMVrtTA+doxycycline) controls.