TABLE 2.
Allele | Penetrance | Other Phenotypes | Ref. # |
---|---|---|---|
Gata5tm1.1Nemr | 7/28 | LVH | (47) |
Tg(GATA5-cre)1Krc/Acvr1tm1Vk | 3/22 | Perimembranous VSDs | (59) |
Nos3tm1Unc | 5/12 | None | (60) |
Hoxa1tm3Mrc | 4/17 | IAA, VSD | (61) |
Tbx1tm1Pa | 5/34 | IAA, TOF, coronary anomalies | (62) |
Hoxa3tm1(cre)Moon/Fgf8tm2Moon | 7/33 | IAA, coronary anomalies | (63) |
Nkx2–5tm1(cre)Rjs/Frs2tm1Fwan | 20% | OA, DORV | (64) |
Nkx2–5tm1Wehi* Nkx2–5tm4Rph* | 11/100 2/98 | Conduction defects, PFO | (65) |
Allele information is taken from Mouse Genome Informatics (http://www.informatics.jax.org).
Heterozygotes.
DORV = double-outlet right ventricle; IAA = interrupted aortic arch; LVH = left ventricular hypertrophy; OA = overriding aorta; PFO = patent foramen ovale; TOF = tetralogy of Fallot; VSD = ventricular septal defect.