Figure 1.

Symptoms and clinical manifestations associated with MARV. Time to onset of symptoms (human) reported are based on the estimated date of infection and symptomatology in cases from South Africa or Germany. Clinical manifestations in NHP are reported as having occurred x number of days after the animal was challenged with MARV. The range for time to onset of symptoms/clinical manifestations of MVD is similar by comparison between each species of NHP—cynomolgus, rhesus, or African green monkey—and humans. In addition, even though some human symptoms (for example, headache, sore throat) cannot be easily discerned in NHP and although some clinical signs (for example, fever) were not always measured in animal studies, common clinical signs of fever, anorexia or weight loss, lethargy or depression or decreased responsiveness, and rash or petechiae were observed consistently in humans and cynomolgus and rhesus macaques.