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Treatment with PD0325901 and temsirolimus inhibits tumor cell signaling. Subcutaneous tumorgrafts of cardiac canine AS non-treated or treated with vehicle, PD0325901, temsirolimus, or PD0325901 plus temsirolimus (PD+T) were stained for H&E and immunostained for CD31, pERK and pS6. Bar, 100 μm.
