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Treatment with PD0325901 and rapamycin inhibits ERK and S6 phosphorylation. (A) VCT261e canine AS primary cell isolates treated with PD0325901 (40 nM) and rapamycin (10 nM) for 72 h. (B) SK-MEL28 cells treated with PD0325901 (5 nM) and rapamycin (6.25 nM) for 72 h. (B) WM-3211 cells treated with PD0325901 (200 nM) and rapamycin (50 nM).
