Table 3. Bioactivities of 5,6-Dihydro-α-pyrones 1–5.
| 1 | 2 | 3 | 4 | 5 | artemisinin | taxol | |
|---|---|---|---|---|---|---|---|
| Dd2 IC50 (μM)a | 9.2 ± 0.9 | 5.8 ± 1.4 | 5.5 ± 0.7 | 7.4 ± 0.6 | 9.0 ± 3.0 | 0.007 ± 0.001 | N/A |
| A2780 IC50 (μM)b | >10 | >10 | 8.6 | >10 | >10 | N/A | 0.028 ± 0.002 |
Antimalarial activity against the Dd2 strain of Plasmodium falciparum
Antiproliferative activity against human ovarian cancer cells.