Table 4. Bioactivities of Bicyclic Tetrahydro-α-pyrone Derivatives 6–11.
| 6 | 7 | 8 | 9 | 10 | 11 | artemisinin | taxol | |
|---|---|---|---|---|---|---|---|---|
| Dd2 IC50 (μM)a | 4.0 ± 2.0 | 6.0 ± 0.5 | >10 | >10 | >10 | >10 | 0.007 ± 0.001 | N/A |
| A2780 IC50 (μM)b | >10 | >10 | >10 | >10 | >10 | >10 | N/A | 0.028 ± 0.002 |
Antimalarial activity against the Dd2 strain of Plasmodium falciparum
Antiproliferative activity against human ovarian cancer cells.