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. 2015 Mar 16;4(7):e1011527. doi: 10.1080/2162402X.2015.1011527

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Figure 1. — HLA ligandome-centric workflow used for the identification of non-mutated targets of antileukemia T-cell responses in patients with chronic lymphocytic leukemia. Comparative analysis of non-mutated HLA ligands presented on peripheral blood mononuclear cells of CLL patients and healthy individuals by mass spectrometry identified the most frequently represented CLL-exclusive antigens. Functional characterization by ELSIPOT assay revealed pre-existing T-cell responses strictly directed against CLL-associated antigens exclusively in CLL patients. Retrospective survival analysis in 45 CLL patients revealed an association of these T-cell responses with improved overall survival.