Figure 1.

(A) Monoclonal antibodies specific for HLA Class I. HLA class I genes are located on chromosome 6p and comprise HLA-A, -B, and -C. The monoclonal antibody HC-10 is reactive for HLA-B and -C. The monoclonal antibody EMR8–5 is reactive for HLA-A, -B, and -C. (B) Immunological cell death (ICD) might play a role in chemotherapy sensitivity in human ovarian cancer. Cancer cells undergoing immunologic cell death release calreticulin (CRT), adenosine triphosphate (ATP), and High Mobility Group Box 1 (HMGB1) and activate dendritic cells (DCs) to induce a cancer-specific cytotoxic T lymphocyte (CTL) response.