Table 2.
Univariate analysis of overall survival and immune parameters
| Marker | Tumor | Stroma | ||||||
|---|---|---|---|---|---|---|---|---|
| N (%) | Median OS | 95%CI | P-value* | N (%) | Median OS | 95%CI | P-value* | |
| CD3 | ||||||||
| Low | 54 (25) | 14.3 | (9.4, 24.9) | 0.57 | 143 (67) | 16.2 | (13.8, 19.4) | 0.52 |
| High | 162 (75) | 16.8 | (15.0, 19.8) | 72 (33) | 17.4 | (15.0, 23.3) | ||
| CD4 | ||||||||
| Low | 113 (52) | 15.2 | (10.6, 19.2) | 0.04 | 28 (13) | 15.0 | (7.4, 21.9) | 0.26 |
| High | 105 (48) | 17.0 | (14.5, 24.8) | 188 (87) | 17.0 | (14.9, 20.1) | ||
| CD8 | ||||||||
| Low | 86 (40) | 14.7 | (12.0, 19.8) | 0.061 | 94 (44) | 18.9 | (14.7, 23.0) | 0.68 |
| High | 131 (60) | 17.0 | (14.5, 21.0) | 120 (56) | 15.3 | (12.5, 18.1) | ||
| CD45RO | ||||||||
| Low | 93 (61) | 16.3 | (14.5, 23.8) | 0.98 | 133 (86) | 16.2 | (14.6, 19.4) | 0.72 |
| High | 60 (39) | 15.0 | (9.8, 20.9) | 21 (14) | 17.4 | (10.1, 38.9) | ||
| CD20 | ||||||||
| Low | 128 (59) | 14.5 | (10.5, 16.8) | 0.003 | 94 (44) | 15.0 | (11.4, 18.9) | 0.21 |
| High | 89 (41) | 20.7 | (16.3, 26.9) | 119 (56) | 18.1 | (15.2, 23.3) | ||
| FoxP3 | ||||||||
| Low | 142 (65) | 16.1 | (14.0, 19.9) | 0.58 | 140 (66) | 16.2 | (14.3, 20.1) | 0.87 |
| High | 75 (35) | 16.8 | (11.4, 21.1) | 72 (34) | 17.0 | (15.0, 21.1) | ||
| CD68 | ||||||||
| Low | 172 (79) | 16.3 | (14.3, 19.8) | 0.87 | 22 (10) | 22.0 | (16.2, 61.1) | 0.067 |
| High | 47 (21) | 16.9 | (10.9, 23.4) | 193 (90) | 16.3 | (14.5, 19.2) | ||
| CD163 | ||||||||
| Low | 112 (53) | 19.1 | (15.1, 23.4) | 0.49 | 133 (67) | 18.1 | (15.1, 22.4) | 0.12 |
| High | 98 (47) | 15.0 | (10.6, 18.1) | 66 (33) | 14.5 | (10.3, 17.0) | ||
| IL-7R | ||||||||
| Low | 116 (53) | 19.3 | (16.3, 26.4) | 0.007 | † | |||
| High | 103 (47) | 14.0 | (10.6, 18.1) | |||||
| IL-12Rβ2 | ||||||||
| Low | 112 (75) | 15.4 | (13.8, 19.1) | 0.067 | † | |||
| High | 38 (25) | 19.9 | (14.5, 41.6) | |||||
| CCR7 | ||||||||
| Low | 123 (79) | 15.2 | (14.0, 18.1) | 0.16 | † | |||
| High | 33 (21) | 28.1 | (15.0, 45.5) | |||||
| CXCL12 | ||||||||
| Low | 55 (36) | 15.4 | (11.4, 18.1) | 0.49 | † | |||
| High | 99 (64) | 16.8 | (15.0, 23.4) | |||||
| CXCR4 | ||||||||
| Low | 104 (69) | 15.0 | (12.5, 17.6) | 0.081 | † | |||
| High | 46 (31) | 21.9 | (12.4, 35.2) | |||||
Abbreviations: CI = confidence interval; FoxP3 = forkhead box P3; IL-7R = interleukin-7 receptor; IL-12Rβ2 = interleukin-12 receptor β2; OS = overall survival (months).
Statistical analysis was performed by log-rank test; significant P-values (<0.05) are shown in bold type.
†
Stroma not applicable for this marker.
*
Adjusted for search of optimal cut-point.