Figure 3.

Influence of FcIL-7, NHS-IL12/FcIL-7, and NHS-IL12/IL-2MAB602 on innate immunity. (A) Tumor homogenates of individuals in each cohort were subjected to RT-PCR–based fragment length analysis for the major triggering receptors NKG2C, -D, and -E, DNAM-1, and NK receptors NKp30, −44, and −46. Note the high congruity within a cohort. (B) TCR transcripts indicative of iNKT cells (invariant Vα24 and Vβ11), Vδ1 and −2 chains, and NKp46 at day 52. (C) TCRVα24 mRNA expression in A204 tumors detected as a single peak or in Gaussian distribution. (D) Expression of CD161 in homogenates of tumors and muscles. Quantitative values are given as mean fluorescence intensity. Each dot represents 1 individual tumor. **P ≤ 0.01, ***P ≤ 0.001.