Table 1.
Differences in vessel structure and function between control and NG2 null mice
| Parameter | Change (vs. control mice) | |||
|---|---|---|---|---|
| Germline-NG2ko mice | PC-NG2ko mice | Mac-NG2ko mice | ||
| Vessel structure | ||||
| Pericyte coverage of endothelial cells | 45% decrease | 33% decrease | 47% decrease | |
| Detached pericyte | 200% increase | Unchanged | 181% increase | |
| Vessel diameter | 20% decrease* | Unchanged | 53% decrease | |
| Basal lamina assembly | 73% decrease | 31% decrease | 72% decrease | |
| N-cadherin (endothelial cell) | N.D. | Unchanged | 74% decrease | |
| N-cadherin (pericyte) | N.D. | Unchanged | 97% decrease | |
| Vessel function | ||||
| Vessel patency | 50% decrease | 43% decrease | 48% decrease | |
| Vessel leakiness | 400% increase | 270% increase | 416% increase | |
| Intratumoral hypoxia | 2000% increase | 560% increase | 1580% increase | |
*
Change in vessel diameter of spontaneous mammary tumors between control and global-NG2 ko mice.6
N.D. = not determined.