Table 5.
Comparison among the JOIN, MOSAIC, MASCOT, and NSABP C-08 trials
| JOIN (n = 828) | MOSAIC (n = 1123) | MASCOT (n = 159) | NSABP C-08 (n = 1350) | |
|---|---|---|---|---|
| Median number of courses | 12 | 12 | 12 | – |
| Treatment completion rate (%) | 67.0 | 74.7 | 81.8 | – |
| Median total dose of L-OHP (mg/m2) | 811.1 | 810.0 | – | 850.0 |
| Median RDI of L-OHP (%) | 78.2 | 80.5 | 84.0a | 95.4 |
| Adverse events (grade ≥ 3) | ||||
| Neutropenia (%) | 28.7 | 41.0c | 52.2 | 32.6d |
| PSN (%) | 5.8 (3.3b) | 12.4c | 5.7 | 14.4d |
| AR (%) | 1.7 | 2.9c | 3.1 | 4.7d |
aCalculated from the dose intensity described in the report
bPSN persisting for at least 8 days that interfered with daily activities
cBased on the data for 1.108 subjects
dBased on the data for 1321 subjects