Table 3.
Severity of dry eye symptoms at baseline and after 30 days of using PEG/PG lubricant eyedrops four times daily
| Variablea | Baseline
|
Day 30
|
P-valuec | ||||
|---|---|---|---|---|---|---|---|
| nb | Mean (SD) | Range | nb | Mean (SD) | Range | ||
| DEWS score | 32 | 2.10 (0.90) | 0–4 | 32 | 0.82 (0.83) | 0–2 | <0.0001 |
| OSDI score | 16 | 41.54 (23.62) | 10–93.75 | 16 | 32.91 (23.16) | 4.55–91.66 | 0.0204 |
| Conjunctival staining | 32 | 0.56 (0.88) | 0–3 | 32 | 0.24 (0.50) | 0–2 | 0.1057 |
| Corneal staining | 32 | 5.38 (3.63) | 0–13 | 32 | 2.71 (3.08) | 0–12 | <0.0001 |
| Tear film break-up time, seconds | 32 | 2.39 (1.64) | 0.90–9.67 | 32 | 4.19 (2.25) | 1.29–11.89 | <0.0001 |
| Schirmer testing, mm | 32 | 13.44 (7.81) | 4–35 | 32 | 12.82 (6.80) | 4–35 | 0.5859 |
| % HLA-DR+ | 32 | 7.17 (6.10) | 1.07–13.27 | 32 | 3.77 (2.12) | 0.70–8.97 | 0.0212 |
Notes:
a
Potential score ranges: DEWS score, 0–4; OSDI score, 0–100; conjunctival staining score, 0–6; corneal staining score, 0–15.
b
Sample sizes reflect number of eyes for all assessments other than the OSDI questionnaire, which was based on number of patients.
c
P-values reflect results of paired t-tests for within-patient comparisons of assessments at baseline versus day 30. Statistical significance is indicated with bold text.
Abbreviations: DEWS, Dry Eye WorkShop; HLA-DR, human leukocyte antigen D-related; OSDI, Ocular Surface Disease Index; PEG, polyethylene glycol; PG, propylene glycol.