Table 3.
Ingenuity pathway analysis tool mapped the genes identified in gene expression vs. cytotoxicity analysis to 5 networks
| ID | Molecules in Network | Score | Focus Molecules | Top Functions |
|---|---|---|---|---|
| 1 | arginase,BCL6,BCR (complex),CXCL9,ERK1/2,Fc gamma receptor,Fcgr3,GCNT2,Gm-csf,GOT,IFN Beta,IFN type 1,Iga,Ige,IgG1,IgG,IgG2a,IgG2b,Igm,IL13,IL19,IL-2R,IL12 (complex),IL12 (family),IL12RB2,IL2RA,Immunoglobulin,Interferon alpha,JAK1,myosin-light-chain kinase,PRF1,RAB27A,SLC12A6,TH2 Cytokine,THBD | 26 | 12 | Cellular Movement, Inflammatory Response, Cell-To-Cell Signaling and Interaction |
| 2 | 26 s Proteasome,ADIRF,beta-estradiol,C16orf59,CLYBL,DNAH17,DPYSL3,FAM111A, FAM134C,FAS,FEZ1,FSH,GEMIN8,GPR107,Gsk3,GTPBP6,HAP1,HIST3H2BB,HS1BP3, KIAA0922,KRT83,LHFPL2,LOC391322,MAGEA8,MYEOV,PXMP4,RNF212,TMEM164, TMEM258,TMEM150C,UBC,UBIAD1,ZNF20,ZNF691,ZNF75D | 21 | 10 | Cell Death and Survival, Cellular Function and Maintenance, Molecular Transport |
| 3 | ABCB11,AFAP1L2,caspase,CHRNE,Ck2,CRTAC1,EDARADD,ERK,Hdac,Histone h3,Histone h4,HOXB6,Hsp90,Ifn,IFN alpha/beta,IFNG,IKK (complex),IL1,Insulin,Jnk,JUN,NFkB (complex),p85 (pik3r),Pka,PKP1,Pro-inflammatory Cytokine,Rac,Ras,Ras homolog,RNA polymerase II,Rxr,STAT,TCR,TSH,Vegf | 18 | 9 | Cancer, Dermatological Diseases and Conditions, Developmental Disorder |
| 4 | Akt,Ap1,calpain,CCND1,CD3,CDK20,Cg,CLDN11,Collagen type I,Collagen(s),Creb,CSF1,Cyclin A,Cyclin E,DTX1,Fcer1,GPC3,Hsp27,Ifn gamma,Integrin,LDL,MAP2K1/2,Mapk,MAPKAPK2,Mek,P38 MAPK,Pdgf (complex),PDGF BB,PI3K (complex),PLC gamma,Rb,Rock,STAT5a/b,Tgf beta,Tnf (family) | 14 | 7 | Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking |
| 5 | D-xylose 1-dehydrogenase (NADP),DHDH,trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 2 | 1 | Carbohydrate Metabolism |